What is MK 2866 or Ostarine?

TL;DR: Ostarine is one of the most studied SARMs out there, it aids in skeletal mass development in adults as well as building lean muscle mass in healthy adult men and cancer patients alike.

MK2866, Ostarine, GTx-024, or Enobosarm, is in class of drugs called SARMs, or Selective Androgen Receptor Modulators. This is the most studied SARM that exists, it passed Phase III clinical trials entitled for “Prevention and treatment of muscle Wasting in patients with Cancer1 (POWER1) and POWER2 evaluating enobosarm for the prevention and treatment of muscle wasting in patients with nonsmall cell lung cancer will be available soon, and will potentially establish a SARM, enobosarm, as the first drug for the prevention and treatment of muscle wasting in cancer patients.” (1)

“GTx-024 (ostarine) is a nonsteroidal SARM that increases muscle mass with only limited effects on seminal vesicles in preclinical studies. Trials in healthy elderly men and in cancer patients with muscle wasting have reported increased lean body mass and improved physical function in the GTx-024-treated groups compared with placebo, making this compound a strong candidate for further clinical development.”

Moreover, Ostarine increases muscle mass in healthy adults, cancer patients. This is proven in a study by the Oxford Academic Endocrinology scientific journal. The journal reports that: “GTx-024 (ostarine) is a nonsteroidal SARM that increases muscle mass with only limited effects on seminal vesicles in preclinical studies. Trials in healthy elderly men and in cancer patients with muscle wasting have reported increased lean body mass and improved physical function in the GTx-024-treated groups compared with placebo, making this compound a strong candidate for further clinical development.” (2)

MK 2866 is selective and only binds to bone and muscle androgen receptors. This action prevents things like prostate issues or hair loss or any of the other nasty side effects anabolic steroids can result in. Ostarine is not suppressive to the HPTA in a short 4 week cycle of 25mg a day, but can become suppressive, to a small degree, if use is continued too long or higher doses are used.

MK2866 does not aromatize into estrogen. In addition, Ostarine is proven to be non-hepatoxic. Thus, it allows for longer possible cycle durations than the typical oral steroid cycle.

MK2866 is anti-catabolic and shines in this department. This means that even in low calorie environments you can keep your muscle instead of it wasting away.

Dalton notes that so far the drugs are “generally well-tolerated” in clinical trials, but none of them have ever reached final approval by a regulatory body.

One SARM in particular, MK2866 / Ostarine, has made it through phase III clinical trials.

DATASHEET FOR MK 2866, Ostarine, ebonosarm GTx-024

Purity: 99.2%

Dosage: 20mg/mL ±10%

Application: Selective Androgen Receptor Modulator

CAS: 841205-47-8

Molar Mass:389.33 g/mol

Chemical Formula:C₁₉H₁₄F₃N₃O₃

IUPAC Name:((2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide)

Synonyms: Ostarine, Enobosarm, GTx-024, MK-2866

Storage: Room temperature

Solubility: PEG400, Ethanol

Physical Form: Solution in PEG400

Sources:

(1) Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer.

(2) Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.

Read more about MK 2866 / Ostarine

EFFECT OF OSTARINE (ENOBOSARM/GTX024), A SELECTIVE ANDROGEN RECEPTOR MODULATOR, ON ADIPOCYTE METABOLISM IN WISTAR RATS

The Selective Androgen Receptor Modulator Ostarine Improves Bone Healing in Ovariectomized Rats.